Efficacy, patterns of use and cost of Pertuzumab in the treatment of HER2+ metastatic breast cancer in Singapore: The National Cancer Centre Singapore experience

Por Rahardja, Sylwan, Tan, Ryan Ying Cong, Sultana, Rehena, Leong, Fun Loon, Lim, Elaine Hsuen
Publicado no World J Clin Oncol (2020)

Enabling multiplexed testing of pooled donor cells through whole-genome sequencing

Por Chan, Yingleong, Chan, Ying Kai, Goodman, Daniel B., Guo, Xiaoge, Chavez, Alejandro, Lim, Elaine T., Church, George M.
Publicado no Genome Med (2018)

Germline Mutations Affecting Gα(11) in Hypoparathyroidism

Por Mannstadt, Michael, Harris, Mark, Bravenboer, Bert, Chitturi, Sridhar, Dreijerink, Koen M.A., Lambright, David G., Lim, Elaine T., Daly, Mark J., Gabriel, Stacey, Jüppner, Harald
Publicado em 2013

CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination

Por Ravindranath, Abhilash K., Kaur, Swayamjot, Wernyj, Roman P., Kumaran, Muthu N., Miletti-Gonzalez, Karl E., Chan, Rigel, Lim, Elaine, Madura, Kiran, Rodriguez-Rodriguez, Lorna
Publicado no Oncotarget (2015)

An Excess of Risk-Increasing Low-Frequency Variants Can Be a Signal of Polygenic Inheritance in Complex Diseases

Por Chan, Yingleong, Lim, Elaine T., Sandholm, Niina, Wang, Sophie R., McKnight, Amy Jayne, Ripke, Stephan, Daly, Mark J., Neale, Benjamin M., Salem, Rany M., Hirschhorn, Joel N.
Publicado em 2014

No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia

Por Ruderfer, Douglas M, Lim, Elaine T, Genovese, Giulio, Moran, Jennifer L, Hultman, Christina M, Sullivan, Patrick F, McCarroll, Steven A, Holmans, Peter, Sklar, Pamela, Purcell, Shaun M
Publicado no Eur J Hum Genet (2015)

An unbiased index to quantify participant’s phenotypic contribution to an open-access cohort

Por Chan, Yingleong, Tung, Michael, Garruss, Alexander S., Zaranek, Sarah W., Chan, Ying Kai, Lunshof, Jeantine E., Zaranek, Alexander W., Ball, Madeleine P., Chou, Michael F., Lim, Elaine T., Church, George M.
Publicado no Sci Rep (2017)

Whole-Exome Sequencing and Homozygosity Analysis Implicate Depolarization-Regulated Neuronal Genes in Autism

Por Chahrour, Maria H., Yu, Timothy W., Lim, Elaine T., Ataman, Bulent, Coulter, Michael E., Hill, R. Sean, Stevens, Christine R., Schubert, Christian R., Greenberg, Michael E., Gabriel, Stacey B., Walsh, Christopher A.
Publicado em 2012

A Novel Test for Recessive Contributions to Complex Diseases Implicates Bardet-Biedl Syndrome Gene BBS10 in Idiopathic Type 2 Diabetes and Obesity

Por Lim, Elaine T., Liu, Yangfan P., Chan, Yingleong, Tiinamaija, Tuomi, Käräjämäki, AnnMari, Madsen, Erik, Altshuler, David M., Raychaudhuri, Soumya, Groop, Leif, Flannick, Jason, Hirschhorn, Joel N., Katsanis, Nicholas, Daly, Mark J.
Publicado no Am J Hum Genet (2014)

DGAT1 mutation is linked to a congenital diarrheal disorder

Por Haas, Joel T., Winter, Harland S., Lim, Elaine, Kirby, Andrew, Blumenstiel, Brendan, DeFelice, Matthew, Gabriel, Stacey, Branski, David, Grueter, Carrie A., Toporovski, Mauro S., Walther, Tobias C., Daly, Mark J., Farese, Robert V., Jalas, Chaim
Publicado em 2012

Integrated Model of De Novo and Inherited Genetic Variants Yields Greater Power to Identify Risk Genes

Por He, Xin, Sanders, Stephan J., Liu, Li, De Rubeis, Silvia, Lim, Elaine T., Sutcliffe, James S., Schellenberg, Gerard D., Gibbs, Richard A., Daly, Mark J., Buxbaum, Joseph D., State, Matthew W., Devlin, Bernie, Roeder, Kathryn
Publicado em 2013

High Densities of Tumor-Associated Plasma Cells Predict Improved Prognosis in Triple Negative Breast Cancer

Por Yeong, Joe, Lim, Jeffrey Chun Tatt, Lee, Bernett, Li, Huihua, Chia, Noel, Ong, Clara Chong Hui, Lye, Weng Kit, Putti, Thomas Choudary, Dent, Rebecca, Lim, Elaine, Thike, Aye Aye, Tan, Puay Hoon, Iqbal, Jabed
Publicado no Front Immunol (2018)

Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development

Por Chan, Yingleong, Salem, Rany M., Hsu, Yu-Han H., McMahon, George, Pers, Tune H., Vedantam, Sailaja, Esko, Tonu, Guo, Michael H., Lim, Elaine T., Franke, Lude, Smith, George Davey, Strachan, David P., Hirschhorn, Joel N.
Publicado no Am J Hum Genet (2015)

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

Por Meyer, Katharina, Feldman, Heather M., Lu, Tao, Drake, Derek, Lim, Elaine T., Ling, King-Hwa, Bishop, Nicholas A., Pan, Ying, Seo, Jinsoo, Lin, Yuan-Ta, Su, Susan C., Church, George M., Tsai, Li-Huei, Yankner, Bruce A.
Publicado no Cell Rep (2019)

Recessive gene disruptions in autism spectrum disorder

Por Doan, Ryan N, Lim, Elaine T., De Rubeis, Silvia, Betancur, Catalina, Cutler, David J., Chiocchetti, Andreas G., Overman, Lynne M., Soucy, Aubrie, Goetze, Susanne, Freitag, Christine M., Daly, Mark J., Walsh, Christopher A., Buxbaum, Joseph D., Yu, Timothy W.
Publicado no Nat Genet (2019)

A Homozygous Mutation in KCTD7 Links Neuronal Ceroid Lipofuscinosis to the Ubiquitin-Proteasome System

Por Staropoli, John F., Karaa, Amel, Lim, Elaine T., Kirby, Andrew, Elbalalesy, Naser, Romansky, Stephen G., Leydiker, Karen B., Coppel, Scott H., Barone, Rosemary, Xin, Winnie, MacDonald, Marcy E., Abdenur, Jose E., Daly, Mark J., Sims, Katherine B., Cotman, Susan L.
Publicado em 2012

Identification of Function for CD44 Intracytoplasmic Domain (CD44-ICD): MODULATION OF MATRIX METALLOPROTEINASE 9 (MMP-9) TRANSCRIPTION VIA NOVEL PROMOTER RESPONSE ELEMENT

Por Miletti-González, Karl E., Murphy, Kyle, Kumaran, Muthu N., Ravindranath, Abhilash K., Wernyj, Roman P., Kaur, Swayamjot, Miles, Gregory D., Lim, Elaine, Chan, Rigel, Chekmareva, Marina, Heller, Debra S., Foran, David, Chen, Wenjin, Reiss, Michael, Bandera, Elisa V., Scotto, Kathleen, Rodríguez-Rodríguez, Lorna
Publicado em 2012

Detection and prognostic relevance of circulating tumour cells (CTCs) in Asian breast cancers using a label-free microfluidic platform

Por Yap, Yoon-Sim, Leong, Man Chun, Chua, Yong Wei, Loh, Kiley Wei Jen, Lee, Guek Eng, Lim, Elaine Hsuen, Dent, Rebecca, Ng, Raymond Chee Hui, Lim, John Heng-Chi, Singh, Garima, Tan, Angela, Guan, Guofeng, Wu, Andrew, Lee, Yi Fang, Bhagat, Ali Asgar S., Lim, Darren Wan-Teck
Publicado no PLoS One (2019)

An enhanced CRISPR repressor for targeted mammalian gene regulation

Por Yeo, Nan Cher, Chavez, Alejandro, Lance-Byrne, Alissa, Chan, Yingleong, Menn, David, Milanova, Denitsa, Kuo, Chih-Chung, Guo, Xiaoge, Sharma, Sumana, Tung, Angela, Cecchi, Ryan J., Tuttle, Marcelle, Pradhan, Swechchha, Lim, Elaine T, Davidsohn, Noah, Ebrahimkhani, Mo R., Collins, James J., Lewis, Nathan E., Kiani, Samira, Church, George M.
Publicado no Nat Methods (2018)

Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer

Por Yeong, Joe, Lim, Jeffrey Chun Tatt, Lee, Bernett, Li, Huihua, Ong, Clara Chong Hui, Thike, Aye Aye, Yeap, Wei Hseun, Yang, Yi, Lim, Ansel Yi Herh, Tay, Timothy Kwang Yong, Liu, Jin, Wong, Siew-Cheng, Chen, Jinmiao, Lim, Elaine Hsuen, Iqbal, Jabed, Dent, Rebecca, Newell, Evan W., Tan, Puay Hoon
Publicado no J Immunother Cancer (2019)