REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

The molecular basis of the earliest neuronal changes that lead to Alzheimer’s disease (AD) is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene-edited and control induced pluripotent stem cells (iPSCs). We observe major differences in iPSC-derived neural progenitor (N...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Meyer, Katharina, Feldman, Heather M., Lu, Tao, Drake, Derek, Lim, Elaine T., Ling, King-Hwa, Bishop, Nicholas A., Pan, Ying, Seo, Jinsoo, Lin, Yuan-Ta, Su, Susan C., Church, George M., Tsai, Li-Huei, Yankner, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386196/
https://ncbi.nlm.nih.gov/pubmed/30699343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.01.023
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