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Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic (13)C magnetic resonance spectroscopy

Despite the central role of the liver in the regulation of glucose and lipid metabolism there are currently no methods to directly assess hepatic oxidative metabolism in humans in vivo. By utilizing a novel (13)C-labeling strategy in combination with (13)C magnetic resonance spectroscopy we show tha...

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Detalhes bibliográficos
Main Authors: Befroy, Douglas E., Perry, Rachel J., Jain, Nimit, Dufour, Sylvie, Cline, Gary W., Trimmer, Jeff, Brosnan, Julia, Rothman, Douglas L., Petersen, Kitt Falk, Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947269/
https://ncbi.nlm.nih.gov/pubmed/24317120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3415
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