Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer

The somatic mutations in a cancer genome are the aggregate outcome of one or more mutational processes operative through the life of the cancer patient(1-3). Each mutational process leaves a characteristic mutational signature determined by the mechanisms of DNA damage and repair that constitute it....

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Detalhes bibliográficos
Main Authors: Nik-Zainal, Serena, Wedge, David C., Alexandrov, Ludmil B., Petljak, Mia, Butler, Adam P., Bolli, Niccolo, Davies, Helen R., Knappskog, Stian, Martin, Sancha, Papaemmanuil, Elli, Ramakrishna, Manasa, Shlien, Adam, Simonic, Ingrid, Xue, Yali, Tyler-Smith, Chris, Campbell, Peter J., Stratton, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137149/
https://ncbi.nlm.nih.gov/pubmed/24728294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2955
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