The intestinal stem cell

Por Barker, Nick, van de Wetering, Marc, Clevers, Hans
Publicado em 2008

All Tcf HMG box transcription factors interact with Groucho-related co-repressors

Por Brantjes, Helen, Roose, Jeroen, van de Wetering, Marc, Clevers, Hans
Publicado em 2001

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes

Por Schepers, Arnout G, Vries, Robert, van den Born, Maaike, van de Wetering, Marc, Clevers, Hans
Publicado em 2011

Wnt Activation and Alternative Promoter Repression of LEF1 in Colon Cancer

Por Li, Tony W.-H., Ting, Ju-Hui T., Yokoyama, Noriko N., Bernstein, Alla, van de Wetering, Marc, Waterman, Marian L.
Publicado em 2006

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

Por Blache, Philippe, van de Wetering, Marc, Duluc, Isabelle, Domon, Claire, Berta, Philippe, Freund, Jean-Noël, Clevers, Hans, Jay, Philippe
Publicado em 2004

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

Por Bartfeld, Sina, Bayram, Tülay, van de Wetering, Marc, Huch, Meritxell, Begthel, Harry, Kujala, Pekka, Vries, Robert, Peters, Peter J, Clevers, Hans
Publicado no Gastroenterology (2014)

Efficient Double Fragmentation ChIP-seq Provides Nucleotide Resolution Protein-DNA Binding Profiles

Por Mokry, Michal, Hatzis, Pantelis, de Bruijn, Ewart, Koster, Jan, Versteeg, Rogier, Schuijers, Jurian, van de Wetering, Marc, Guryev, Victor, Clevers, Hans, Cuppen, Edwin
Publicado em 2010

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2

Por Simmini, Salvatore, Bialecka, Monika, Huch, Meritxell, Kester, Lennart, van de Wetering, Marc, Sato, Toshiro, Beck, Felix, van Oudenaarden, Alexander, Clevers, Hans, Deschamps, Jacqueline
Publicado no Nat Commun (2014)

Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

Por Lustig, Barbara, Jerchow, Boris, Sachs, Martin, Weiler, Sigrid, Pietsch, Torsten, Karsten, Uwe, van de Wetering, Marc, Clevers, Hans, Schlag, Peter M., Birchmeier, Walter, Behrens, Jürgen
Publicado em 2002

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector

Por van de Wetering, Marc, Oving, Irma, Muncan, Vanesa, Pon Fong, Menno Tjon, Brantjes, Helen, van Leenen, Dik, Holstege, Frank C.P., Brummelkamp, Thijn R., Agami, Reuven, Clevers, Hans
Publicado em 2003

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Por Sato, Toshiro, van Es, Johan H., Snippert, Hugo J., Stange, Daniel E., Vries, Robert G., van den Born, Maaike, Barker, Nick, Shroyer, Noah F., van de Wetering, Marc, Clevers, Hans
Publicado em 2010

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Por Huch, Meritxell, Dorrell, Craig, Boj, Sylvia F., van Es, Johan H., van de Wetering, Marc, Li, Vivian S.W., Hamer, Karien, Sasaki, Nobuo, Finegold, Milton J., Haft, Annelise, Grompe, Markus, Clevers, Hans
Publicado em 2013

Dll1 marks early secretory progenitors in gut crypts that can revert to stem cells upon tissue damage

Por van Es, Johan H., Sato, Toshiro, van de Wetering, Marc, Lyubimova, Anna, Gregorieff, Alex, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Martens, Anton C.M., van den Oudenaarden, Alexander, Clevers, Hans
Publicado em 2012

Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis

Por Berezikov, Eugene, van Tetering, Geert, Verheul, Mark, van de Belt, Jose, van Laake, Linda, Vos, Joost, Verloop, Robert, van de Wetering, Marc, Guryev, Victor, Takada, Shuji, van Zonneveld, Anton Jan, Mano, Hiroyuki, Plasterk, Ronald, Cuppen, Edwin
Publicado em 2006

Differentiated Troy(+) chief cells act as 'reserve' stem cells to generate all lineages of the stomach epithelium

Por Stange, Daniel E., Koo, Bon-Kyoung, Huch, Meritxell, Sibbel, Greg, Basak, Onur, Lyubimova, Anna, Kujala, Pekka, Bartfeld, Sina, Koster, Jan, Geahlen, Jessica H., Peters, Peter J., van Es, Johan H., van de Wetering, Marc, Mills, Jason C., Clevers, Hans
Publicado em 2013

Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells

Por Hatzis, Pantelis, van der Flier, Laurens G., van Driel, Marc A., Guryev, Victor, Nielsen, Fiona, Denissov, Sergei, Nijman, Isaäc J., Koster, Jan, Santo, Evan E., Welboren, Willem, Versteeg, Rogier, Cuppen, Edwin, van de Wetering, Marc, Clevers, Hans, Stunnenberg, Hendrik G.
Publicado em 2008

Lrig1 controls intestinal stem cell homeostasis by negative regulation of ErbB signalling

Por Wong, Vivian W.Y., Stange, Daniel E., Page, Mahalia E., Buczacki, Simon, Wabik, Agnieszka, Itami, Satoshi, van de Wetering, Marc, Poulsom, Richard, Wright, Nicholas A., Trotter, Matthew W.B., Watt, Fiona M., Winton, Doug J., Clevers, Hans, Jensen, Kim B.
Publicado em 2012

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

Por Weeber, Fleur, van de Wetering, Marc, Hoogstraat, Marlous, Dijkstra, Krijn K., Krijgsman, Oscar, Kuilman, Thomas, Gadellaa-van Hooijdonk, Christa G. M., van der Velden, Daphne L., Peeper, Daniel S., Cuppen, Edwin P. J. G., Vries, Robert G., Clevers, Hans, Voest, Emile E.
Publicado no Proc Natl Acad Sci U S A (2015)

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

Por Kaaij, Lucas TJ, van de Wetering, Marc, Fang, Fang, Decato, Benjamin, Molaro, Antoine, van de Werken, Harmen JG, van Es, Johan H, Schuijers, Jurian, de Wit, Elzo, de Laat, Wouter, Hannon, Gregory J, Clevers, Hans C, Smith, Andrew D, Ketting, René F
Publicado em 2013

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4' cell markers

Por Muñoz, Javier, Stange, Daniel E, Schepers, Arnout G, van de Wetering, Marc, Koo, Bon-Kyoung, Itzkovitz, Shalev, Volckmann, Richard, Kung, Kevin S, Koster, Jan, Radulescu, Sorina, Myant, Kevin, Versteeg, Rogier, Sansom, Owen J, van Es, Johan H, Barker, Nick, van Oudenaarden, Alexander, Mohammed, Shabaz, Heck, Albert J R, Clevers, Hans
Publicado em 2012