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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
The Wnt target gene Lgr5 marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon(1), stomach(2) and hair follicles(3). A 3D culture system allows long-term clonal expansion of single Lgr5(+) stem cells into transplantable organoids that retain many c...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3634804/ https://ncbi.nlm.nih.gov/pubmed/23354049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11826 |
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