In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

The Wnt target gene Lgr5 marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as small intestine and colon(1), stomach(2) and hair follicles(3). A 3D culture system allows long-term clonal expansion of single Lgr5(+) stem cells into transplantable organoids that retain many c...

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Autori principali: Huch, Meritxell, Dorrell, Craig, Boj, Sylvia F., van Es, Johan H., van de Wetering, Marc, Li, Vivian S.W., Hamer, Karien, Sasaki, Nobuo, Finegold, Milton J., Haft, Annelise, Grompe, Markus, Clevers, Hans
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634804/
https://ncbi.nlm.nih.gov/pubmed/23354049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11826
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