Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion

Cycling intestinal Lgr5(+) stem cells are intermingled with their terminally differentiated Paneth cell daughters at crypt bottoms. Paneth cells provide multiple secreted (e.g., Wnt, EGF) as well as surface-bound (Notch ligand) niche signals. Here we show that ablation of Paneth cells in mice, using...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: van Es, Johan H., Wiebrands, Kay, López-Iglesias, Carmen, van de Wetering, Marc, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Sasaki, Nobuo, Peters, Peter J., van Oudenaarden, Alexander, Clevers, Hans
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936398/
https://ncbi.nlm.nih.gov/pubmed/31843916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1801888117
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