Mapping early fate determination in Lgr5(+) crypt stem cells using a novel Ki67-RFP allele

Cycling Lgr5(+) stem cells fuel the rapid turnover of the adult intestinal epithelium. The existence of quiescent Lgr5(+) cells has been reported, while an alternative quiescent stem cell population is believed to reside at crypt position +4. Here, we generated a novel Ki67(RFP) knock-in allele that...

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Main Authors: Basak, Onur, van de Born, Maaike, Korving, Jeroen, Beumer, Joep, van der Elst, Stefan, van Es, Johan H, Clevers, Hans
Formato: Artigo
Idioma:Inglês
Publicado: BlackWell Publishing Ltd 2014
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195772/
https://ncbi.nlm.nih.gov/pubmed/25092767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488017
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