Dll1 marks early secretory progenitors in gut crypts that can revert to stem cells upon tissue damage

Lgr5 stem cells reside at small intestinal crypt bottoms, generating both the enterocyte and secretory lineage. Entry into the latter epithelial lineage requires silencing of Notch signaling. The Notch ligand Dll1 is strongly up-regulated in a small subset of immediate stem cell daughters. Lineage t...

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Detalhes bibliográficos
Main Authors: van Es, Johan H., Sato, Toshiro, van de Wetering, Marc, Lyubimova, Anna, Gregorieff, Alex, Zeinstra, Laura, van den Born, Maaike, Korving, Jeroen, Martens, Anton C.M., van den Oudenaarden, Alexander, Clevers, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789123/
https://ncbi.nlm.nih.gov/pubmed/23000963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2581
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