The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4' cell markers

Two types of stem cells are currently defined in small intestinal crypts: cycling crypt base columnar (CBC) cells and quiescent ‘+4' cells. Here, we combine transcriptomics with proteomics to define a definitive molecular signature for Lgr5(+) CBC cells. Transcriptional profiling of FACS-sorted...

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Detalhes bibliográficos
Main Authors: Muñoz, Javier, Stange, Daniel E, Schepers, Arnout G, van de Wetering, Marc, Koo, Bon-Kyoung, Itzkovitz, Shalev, Volckmann, Richard, Kung, Kevin S, Koster, Jan, Radulescu, Sorina, Myant, Kevin, Versteeg, Rogier, Sansom, Owen J, van Es, Johan H, Barker, Nick, van Oudenaarden, Alexander, Mohammed, Shabaz, Heck, Albert J R, Clevers, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400017/
https://ncbi.nlm.nih.gov/pubmed/22692129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.166
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