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Optimality in the Development of Intestinal Crypts

Intestinal crypts in mammals are comprised of long-lived stem cells and shorter-lived progenies. These two populations are maintained in specific proportions during adult life. Here, we investigate the design principles governing the dynamics of these proportions during crypt morphogenesis. Using op...

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Detalhes bibliográficos
Main Authors: Itzkovitz, Shalev, Blat, Irene C., Jacks, Tyler, Clevers, Hans, van Oudenaarden, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696183/
https://ncbi.nlm.nih.gov/pubmed/22304925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.12.025
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