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Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion
The concept of ‘field cancerization’ describes the clonal expansion of genetically altered, but morphologically normal cells that predisposes a tissue to cancer development. Here, we demonstrate that biased stem cell competition in the mouse small intestine can initiate the expansion of such clones....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3983678/ https://ncbi.nlm.nih.gov/pubmed/24355609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embr.201337799 |
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