Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion

Although the existence of cancer stem cells in intestine tumors has been suggested, direct evidence has not been yet provided. Here, we showed, using the multicolor lineage-tracing method and mouse models of intestinal adenocarcinoma and adenoma that Bmi1- or Lgr5- positive tumorigenic cells clonall...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Yanai, Hirotsugu, Atsumi, Naho, Tanaka, Toshihiro, Nakamura, Naohiro, Komai, Yoshihiro, Omachi, Taichi, Tanaka, Kiyomichi, Ishigaki, Kazuhiko, Saiga, Kazuho, Ohsugi, Haruyuki, Tokuyama, Yoko, Imahashi, Yuki, Ohe, Shuichi, Hisha, Hiroko, Yoshida, Naoko, Kumano, Keiki, Kon, Masanori, Ueno, Hiroo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5296906/
https://ncbi.nlm.nih.gov/pubmed/28176811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41838
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