Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

Activation of Wnt signaling through β-catenin/TCF complexes is a key event in the development of various tumors, in particular colorectal and liver tumors. Wnt signaling is controlled by the negative regulator conductin/axin2/axil, which induces degradation of β-catenin by functional interaction wit...

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Detalhes bibliográficos
Main Authors: Lustig, Barbara, Jerchow, Boris, Sachs, Martin, Weiler, Sigrid, Pietsch, Torsten, Karsten, Uwe, van de Wetering, Marc, Clevers, Hans, Schlag, Peter M., Birchmeier, Walter, Behrens, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC134640/
https://ncbi.nlm.nih.gov/pubmed/11809809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.4.1184-1193.2002
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