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Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20

Wnt/β-catenin signalling regulates cell proliferation by modulating the cell cycle and is negatively regulated by conductin/axin2/axil. We show that conductin levels peak at G2/M followed by a rapid decline during return to G1. In line with this, Wnt/β-catenin target genes are low at G2/M and high a...

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Détails bibliographiques
Auteurs principaux: Hadjihannas, Michel V, Bernkopf, Dominic B, Brückner, Martina, Behrens, Jürgen
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321148/
https://ncbi.nlm.nih.gov/pubmed/22322943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.12
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