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Wnt Activation and Alternative Promoter Repression of LEF1 in Colon Cancer
Alternative promoters within the LEF1 locus produce polypeptides of opposing biological activities. Promoter 1 produces full-length LEF-1 protein, which recruits β-catenin to Wnt target genes. Promoter 2 produces a truncated form that cannot interact with β-catenin and instead suppresses Wnt regulat...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1592719/ https://ncbi.nlm.nih.gov/pubmed/16809766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00105-06 |
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