Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

di Wu, Tao, Yoon, Hojong, Xiong, Yuan, Dixon-Clarke, Sarah, Nowak, Radosław P., Fischer, Eric S.
Pubblicato in Nat Struct Mol Biol (2020)

A generic protocol for protein crystal dehydration using the HC1b humidity controller

di Lobley, Carina M. C., Sandy, James, Sanchez-Weatherby, Juan, Mazzorana, Marco, Krojer, Tobias, Nowak, Radosław P., Sorensen, Thomas L.
Pubblicato in Acta Crystallogr D Struct Biol (2016)

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs

di Gasic, Ivana, Groendyke, Brian J., Nowak, Radosław P., Yuan, J. Christine, Kalabathula, Joann, Fischer, Eric S., Gray, Nathanael S., Mitchison, Timothy J.
Pubblicato in Cells (2020)

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

di Donovan, Katherine A, An, Jian, Nowak, Radosław P, Yuan, Jingting C, Fink, Emma C, Berry, Bethany C, Ebert, Benjamin L, Fischer, Eric S
Pubblicato in eLife (2018)

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

di Faust, Tyler, Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., Fischer, Eric S.
Pubblicato in Nat Chem Biol (2019)

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates

di Tarhonskaya, Hanna, Nowak, Radosław P., Johansson, Catrine, Szykowska, Aleksandra, Tumber, Anthony, Hancock, Rebecca L., Lang, Pauline, Flashman, Emily, Oppermann, Udo, Schofield, Christopher J., Kawamura, Akane
Pubblicato in J Mol Biol (2017)

Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library

di Powell, Chelsea E., Du, Guangyan, Che, Jianwei, He, Zhixiang, Donovan, Katherine A., Yue, Hong, Wang, Eric S., Nowak, Radosław P., Zhang, Tinghu, Fischer, Eric S., Gray, Nathanael S.
Pubblicato in ACS Chem Biol (2020)

Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK)

di Powell, Chelsea E., Gao, Yang, Tan, Li, Donovan, Katherine A., Nowak, Radosław P., Loehr, Amanda, Bahcall, Magda, Fischer, Eric S., Jänne, Pasi A., George, Rani E., Gray, Nathanael S.
Pubblicato in J Med Chem (2018)

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

di Pearce, Nicholas M., Krojer, Tobias, Bradley, Anthony R., Collins, Patrick, Nowak, Radosław P., Talon, Romain, Marsden, Brian D., Kelm, Sebastian, Shi, Jiye, Deane, Charlotte M., von Delft, Frank
Pubblicato in Nat Commun (2017)

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

di Thinnes, Cyrille C., Lohans, Christopher T., Abboud, Martine I., Yeh, Tzu‐Lan, Tumber, Anthony, Nowak, Radosław P., Attwood, Martin, Cockman, Matthew E., Oppermann, Udo, Loenarz, Christoph, Schofield, Christopher J.
Pubblicato in Chemistry (2019)

Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations

di de Wispelaere, Mélissanne, Du, Guangyan, Donovan, Katherine A., Zhang, Tinghu, Eleuteri, Nicholas A., Yuan, Jingting C., Kalabathula, Joann, Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S., Yang, Priscilla L.
Pubblicato in Nat Commun (2019)

An integrated approach to quantitative modelling in angiogenesis research

di Connor, Anthony J., Nowak, Radosław P., Lorenzon, Erica, Thomas, Markus, Herting, Frank, Hoert, Stefan, Quaiser, Tom, Shochat, Eliezer, Pitt-Francis, Joe, Cooper, Jonathan, Maini, Philip K., Byrne, Helen M.
Pubblicato in J R Soc Interface (2015)

Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

di Morita, Ken, He, Shuning, Nowak, Radosław P., Wang, Jinhua, Zimmerman, Mark W., Fu, Cong, Durbin, Adam D., Martel, Megan W., Prutsch, Nicole, Gray, Nathanael S., Fischer, Eric S., Look, A. Thomas
Pubblicato in Cell (2020)

Local Deuteration Enables NMR Observation of Methyl Groups in Proteins from Eukaryotic and Cell‐Free Expression Systems

di Dubey, Abhinav, Stoyanov, Nikolay, Viennet, Thibault, Chhabra, Sandeep, Elter, Shantha, Borggräfe, Jan, Viegas, Aldino, Nowak, Radosław P., Burdzhiev, Nikola, Petrov, Ognyan, Fischer, Eric S., Etzkorn, Manuel, Gelev, Vladimir, Arthanari, Haribabu
Pubblicato in Angew Chem Int Ed Engl (2021)

Bruton tyrosine kinase degradation as a therapeutic strategy for cancer

di Dobrovolsky, Dennis, Wang, Eric S., Morrow, Sara, Leahy, Catharine, Faust, Tyler, Nowak, Radosław P., Donovan, Katherine A., Yang, Guang, Li, Zhengnian, Fischer, Eric S., Treon, Steven P., Weinstock, David M., Gray, Nathanael S.
Pubblicato in Blood (2019)

Homolog-selective degradation as a strategy to probe the function of CDK6 in AML

di Brand, Matthias, Jiang, Baishan, Bauer, Sophie, Donovan, Katherine A., Wang, Eric S., Nowak, Radosław P., Yuan, Jingting C., Zhang, Tinghu, Kwiatkowski, Nicholas, Müller, André C., Fischer, Eric S., Gray, Nathanael S., Winter, Georg E.
Pubblicato in Cell Chem Biol (2018)

Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations

di Jang, Jaebong, To, Ciric, De Clercq, Dries J. H., Park, Eunyoung, Ponthier, Charles M., Shin, Bo Hee, Mushajiang, Mierzhati, Nowak, Radosław P., Fischer, Eric S., Eck, Michael J., Jänne, Pasi A., Gray, Nathanael S.
Pubblicato in Angew Chem Int Ed Engl (2020)

Acute pharmacological degradation of Helios destabilizes regulatory T cells

di Wang, Eric S., Verano, Alyssa L., Nowak, Radosław P., Yuan, J. Christine, Donovan, Katherine A., Eleuteri, Nicholas A., Yue, Hong, Ngo, Kenneth H., Lizotte, Patrick H., Gokhale, Prafulla C., Gray, Nathanael S., Fischer, Eric S.
Pubblicato in Nat Chem Biol (2021)

Development and Characterization of a Wee1 Kinase Degrader

di Li, Zhengnian, Pinch, Benika J., Olson, Calla M., Donovan, Katherine A., Nowak, Radosław P., Mills, Caitlin E., Scott, David A., Doctor, Zainab M., Eleuteri, Nicholas A., Chung, Mirra, Sorger, Peter K, Fischer, Eric S., Gray, Nathanael S.
Pubblicato in Cell Chem Biol (2019)

Rapid 'mix and read' assay for scalable detection of SARS-CoV-2 antibodies in patient plasma

di Yue, Hong, Nowak, Radosław P, Overwijn, Daan, Payne, N Connor, Fischinger, Stephanie, Atyeo, Caroline, Baden, Lindsey R, Nilles, Eric James, Karlson, Elizabeth W, Yu, Xu G, Li, Jonathan Z, Alter, Galit, Mazitschek, Ralph, Fischer, Eric S
Pubblicato in medRxiv (2020)