Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

द्वारा Wu, Tao, Yoon, Hojong, Xiong, Yuan, Dixon-Clarke, Sarah, Nowak, Radosław P., Fischer, Eric S.
में प्रकाशित Nat Struct Mol Biol (2020)

A generic protocol for protein crystal dehydration using the HC1b humidity controller

द्वारा Lobley, Carina M. C., Sandy, James, Sanchez-Weatherby, Juan, Mazzorana, Marco, Krojer, Tobias, Nowak, Radosław P., Sorensen, Thomas L.
में प्रकाशित Acta Crystallogr D Struct Biol (2016)

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs

द्वारा Gasic, Ivana, Groendyke, Brian J., Nowak, Radosław P., Yuan, J. Christine, Kalabathula, Joann, Fischer, Eric S., Gray, Nathanael S., Mitchison, Timothy J.
में प्रकाशित Cells (2020)

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

द्वारा Donovan, Katherine A, An, Jian, Nowak, Radosław P, Yuan, Jingting C, Fink, Emma C, Berry, Bethany C, Ebert, Benjamin L, Fischer, Eric S
में प्रकाशित eLife (2018)

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

द्वारा Faust, Tyler, Yoon, Hojong, Nowak, Radosław P., Donovan, Katherine A., Li, Zhengnian, Cai, Quan, Eleuteri, Nicholas A., Zhang, Tinghu, Gray, Nathanael S., Fischer, Eric S.
में प्रकाशित Nat Chem Biol (2019)

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates

द्वारा Tarhonskaya, Hanna, Nowak, Radosław P., Johansson, Catrine, Szykowska, Aleksandra, Tumber, Anthony, Hancock, Rebecca L., Lang, Pauline, Flashman, Emily, Oppermann, Udo, Schofield, Christopher J., Kawamura, Akane
में प्रकाशित J Mol Biol (2017)

Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library

द्वारा Powell, Chelsea E., Du, Guangyan, Che, Jianwei, He, Zhixiang, Donovan, Katherine A., Yue, Hong, Wang, Eric S., Nowak, Radosław P., Zhang, Tinghu, Fischer, Eric S., Gray, Nathanael S.
में प्रकाशित ACS Chem Biol (2020)

Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK)

द्वारा Powell, Chelsea E., Gao, Yang, Tan, Li, Donovan, Katherine A., Nowak, Radosław P., Loehr, Amanda, Bahcall, Magda, Fischer, Eric S., Jänne, Pasi A., George, Rani E., Gray, Nathanael S.
में प्रकाशित J Med Chem (2018)

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

द्वारा Pearce, Nicholas M., Krojer, Tobias, Bradley, Anthony R., Collins, Patrick, Nowak, Radosław P., Talon, Romain, Marsden, Brian D., Kelm, Sebastian, Shi, Jiye, Deane, Charlotte M., von Delft, Frank
में प्रकाशित Nat Commun (2017)

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

द्वारा Thinnes, Cyrille C., Lohans, Christopher T., Abboud, Martine I., Yeh, Tzu‐Lan, Tumber, Anthony, Nowak, Radosław P., Attwood, Martin, Cockman, Matthew E., Oppermann, Udo, Loenarz, Christoph, Schofield, Christopher J.
में प्रकाशित Chemistry (2019)

Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations

द्वारा de Wispelaere, Mélissanne, Du, Guangyan, Donovan, Katherine A., Zhang, Tinghu, Eleuteri, Nicholas A., Yuan, Jingting C., Kalabathula, Joann, Nowak, Radosław P., Fischer, Eric S., Gray, Nathanael S., Yang, Priscilla L.
में प्रकाशित Nat Commun (2019)

An integrated approach to quantitative modelling in angiogenesis research

द्वारा Connor, Anthony J., Nowak, Radosław P., Lorenzon, Erica, Thomas, Markus, Herting, Frank, Hoert, Stefan, Quaiser, Tom, Shochat, Eliezer, Pitt-Francis, Joe, Cooper, Jonathan, Maini, Philip K., Byrne, Helen M.
में प्रकाशित J R Soc Interface (2015)

Allosteric Activators of Protein Phosphatase 2A Display Broad Antitumor Activity Mediated by Dephosphorylation of MYBL2

द्वारा Morita, Ken, He, Shuning, Nowak, Radosław P., Wang, Jinhua, Zimmerman, Mark W., Fu, Cong, Durbin, Adam D., Martel, Megan W., Prutsch, Nicole, Gray, Nathanael S., Fischer, Eric S., Look, A. Thomas
में प्रकाशित Cell (2020)

Local Deuteration Enables NMR Observation of Methyl Groups in Proteins from Eukaryotic and Cell‐Free Expression Systems

द्वारा Dubey, Abhinav, Stoyanov, Nikolay, Viennet, Thibault, Chhabra, Sandeep, Elter, Shantha, Borggräfe, Jan, Viegas, Aldino, Nowak, Radosław P., Burdzhiev, Nikola, Petrov, Ognyan, Fischer, Eric S., Etzkorn, Manuel, Gelev, Vladimir, Arthanari, Haribabu
में प्रकाशित Angew Chem Int Ed Engl (2021)

Bruton tyrosine kinase degradation as a therapeutic strategy for cancer

द्वारा Dobrovolsky, Dennis, Wang, Eric S., Morrow, Sara, Leahy, Catharine, Faust, Tyler, Nowak, Radosław P., Donovan, Katherine A., Yang, Guang, Li, Zhengnian, Fischer, Eric S., Treon, Steven P., Weinstock, David M., Gray, Nathanael S.
में प्रकाशित Blood (2019)

Homolog-selective degradation as a strategy to probe the function of CDK6 in AML

द्वारा Brand, Matthias, Jiang, Baishan, Bauer, Sophie, Donovan, Katherine A., Wang, Eric S., Nowak, Radosław P., Yuan, Jingting C., Zhang, Tinghu, Kwiatkowski, Nicholas, Müller, André C., Fischer, Eric S., Gray, Nathanael S., Winter, Georg E.
में प्रकाशित Cell Chem Biol (2018)

Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations

द्वारा Jang, Jaebong, To, Ciric, De Clercq, Dries J. H., Park, Eunyoung, Ponthier, Charles M., Shin, Bo Hee, Mushajiang, Mierzhati, Nowak, Radosław P., Fischer, Eric S., Eck, Michael J., Jänne, Pasi A., Gray, Nathanael S.
में प्रकाशित Angew Chem Int Ed Engl (2020)

Acute pharmacological degradation of Helios destabilizes regulatory T cells

द्वारा Wang, Eric S., Verano, Alyssa L., Nowak, Radosław P., Yuan, J. Christine, Donovan, Katherine A., Eleuteri, Nicholas A., Yue, Hong, Ngo, Kenneth H., Lizotte, Patrick H., Gokhale, Prafulla C., Gray, Nathanael S., Fischer, Eric S.
में प्रकाशित Nat Chem Biol (2021)

Development and Characterization of a Wee1 Kinase Degrader

द्वारा Li, Zhengnian, Pinch, Benika J., Olson, Calla M., Donovan, Katherine A., Nowak, Radosław P., Mills, Caitlin E., Scott, David A., Doctor, Zainab M., Eleuteri, Nicholas A., Chung, Mirra, Sorger, Peter K, Fischer, Eric S., Gray, Nathanael S.
में प्रकाशित Cell Chem Biol (2019)

Rapid 'mix and read' assay for scalable detection of SARS-CoV-2 antibodies in patient plasma

द्वारा Yue, Hong, Nowak, Radosław P, Overwijn, Daan, Payne, N Connor, Fischinger, Stephanie, Atyeo, Caroline, Baden, Lindsey R, Nilles, Eric James, Karlson, Elizabeth W, Yu, Xu G, Li, Jonathan Z, Alter, Galit, Mazitschek, Ralph, Fischer, Eric S
में प्रकाशित medRxiv (2020)