JAK2-V617F-mediated signalling is dependent on lipid rafts and statins inhibit JAK2-V617F-dependent cell growth

Por Griner, Lori N., McGraw, Kathy L., Johnson, Joseph O., List, Alan F., Reuther, Gary W.
Publicado no Br J Haematol (2012)

Erythropoietin Receptor Signaling Is Membrane Raft Dependent

Por McGraw, Kathy L., Fuhler, Gwenny M., Johnson, Joseph O., Clark, Justine A., Caceres, Gisela C., Sokol, Lubomir, List, Alan F.
Publicado em 2012

HG-829 Is a Potent Noncompetitive Inhibitor of the ATP-Binding Cassette Multidrug Resistance Transporter ABCB1

Por Caceres, Gisela, Robey, Robert W., Sokol, Lubomir, McGraw, Kathy L., Clark, Justine, Lawrence, Nicholas J., Sebti, Said M., Wiese, Michael, List, Alan F.
Publicado no Cancer Res (2012)

Lenalidomide Induces Lipid Raft Assembly to Enhance Erythropoietin Receptor Signaling in Myelodysplastic Syndrome Progenitors

Por McGraw, Kathy L., Basiorka, Ashley A., Johnson, Joseph O., Clark, Justine, Caceres, Gisela, Padron, Eric, Heaton, Ruth, Ozawa, Yukiyasu, Wei, Sheng, Sokol, Lubomir, List, Alan F.
Publicado no PLoS One (2014)

Immunohistochemical pattern of p53 is a measure of TP53 mutation burden and adverse clinical outcome in myelodysplastic syndromes and secondary acute myeloid leukemia

Por McGraw, Kathy L., Nguyen, Johnny, Komrokji, Rami S., Sallman, David, Al Ali, Najla H., Padron, Eric, Lancet, Jeffrey E., Moscinski, Lynn C., List, Alan F., Zhang, Ling
Publicado no Haematologica (2016)

Identification of a risk dependent microRNA expression signature in myelodysplastic syndromes

Por Sokol, Lubomir, Caceres, Gisela, Volinia, Stefano, Alder, Hans, Nuovo, Gerard J., Liu, Chang-Gong, McGraw, Kathy, Clark, Justine A., Sigua, Celia A., Chen, Dung-Tsa, Moscinski, Lynn, Croce, Carlo M., List, Alan F.
Publicado no Br J Haematol (2011)

Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41

Por Basiorka, Ashley A, McGraw, Kathy L, De Ceuninck, Leentje, Griner, Lori N, Zhang, Ling, Clark, Justine A, Caceres, Gisela, Sokol, Lubomir, Komrokji, Rami S, Reuther, Gary W, Wei, Sheng, Tavernier, Jan, List, Alan F
Publicado no Cancer Res (2016)

TP53 and MDM2 single nucleotide polymorphisms influence survival in non-del(5q) myelodysplastic syndromes

Por McGraw, Kathy L., Cluzeau, Thomas, Sallman, David A., Basiorka, Ashley A., Irvine, Brittany A., Zhang, Ling, Epling-Burnette, P.K., Rollison, Dana E., Mallo, Mar, Sokol, Lubomir, Solé, Francesc, Maciejewski, Jaroslaw, List, Alan F.
Publicado no Oncotarget (2015)

Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide

Por Sugimoto, Yuka, Sekeres, Mikkael A, Makishima, Hideki, Traina, Fabiola, Visconte, Valeria, Jankowska, Anna, Jerez, Andres, Szpurka, Hadrian, O'Keefe, Christine L, Guinta, Kathryn, Afable, Manuel, Tiu, Ramon, McGraw, Kathy L, List, Alan F, Maciejewski, Jaroslaw
Publicado em 2012

Naïve T-cells in Myelodysplastic Syndrome Display Intrinsic Human Telomerase Reverse Transcriptase (hTERT) Deficiency

Por Yang, Lili, Mailloux, Adam, Rollison, Dana E., Painter, Jeffrey S., Maciejewski, Jaroslaw, Paquette, Ronald L., Loughran, Thomas P., McGraw, Kathy, Makishima, Hideki, Radhakrishnan, Rangasudhagar, Wei, Sheng, Ren, Xiubao, Komrokji, Rami, List, Alan F., Epling-Burnette, P.K.
Publicado no Leukemia (2012)

GM-CSF–dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia

Por Padron, Eric, Painter, Jeffrey S., Kunigal, Sateesh, Mailloux, Adam W., McGraw, Kathy, McDaniel, Jessica M., Kim, Eunhee, Bebbington, Christopher, Baer, Mark, Yarranton, Geoffrey, Lancet, Jeffrey, Komrokji, Rami S., Abdel-Wahab, Omar, List, Alan F., Epling-Burnette, Pearlie K.
Publicado no Blood (2013)

Molecular predictors of response in patients with myeloid neoplasms treated with lenalidomide

Por Negoro, Eiju, Radivoyevitch, Tomas, Polprasert, Chantana, Adema, Vera, Hosono, Naoko, Makishima, Hideki, Przychodzen, Bartlomiej, Hirsch, Cassandra, Clemente, Michael J., Nazha, Aziz, Santini, Valeria, McGraw, Kathy L., List, Alan F., Sole, Francesc, Sekeres, Mikkael A., Maciejewski, Jaroslaw P.
Publicado no Leukemia (2016)

Lenalidomide Promotes p53 Degradation by Inhibiting MDM2 Auto-ubiquitination in Myelodysplastic Syndrome with Chromosome 5q Deletion

Por Wei, Sheng, Chen, Xianghong, McGraw, Kathy, Zhang, Ling, Komrokji, Rami, Clark, Justine, Caceres, Gisela, Billingsley, Debbie, Sokol, Lubomir, Lancet, Jeffrey, Fortenbery, Nicole, Zhou, Junmin, Eksioglu, Erika A., Sallman, David, Wang, Huaquan, Epling-Burnette, Pearlie K., Djeu, Julie, Maciejewski, Jaroslaw P., Sekeres, Mikkael, List, Alan
Publicado em 2012

TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients

Por Caceres, Gisela, McGraw, Kathy, Yip, Bon Ham, Pellagatti, Andrea, Johnson, Joseph, Zhang, Ling, Liu, Kenian, Zhang, Lan Min, Fulp, William J., Lee, Ji-Hyun, Al Ali, Najla H., Basiorka, Ashley, Smith, Larry J., Daugherty, F. Joseph, Littleton, Neil, Wells, Richard A., Sokol, Lubomir, Wei, Sheng, Komrokji, Rami S., Boultwood, Jacqueline, List, Alan F.
Publicado em 2013

STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia

Por Jerez, Andres, Clemente, Michael J., Makishima, Hideki, Koskela, Hanna, LeBlanc, Francis, Peng Ng, Kwok, Olson, Thomas, Przychodzen, Bartlomiej, Afable, Manuel, Gomez-Segui, Ines, Guinta, Kathryn, Durkin, Lisa, Hsi, Eric D., McGraw, Kathy, Zhang, Dan, Wlodarski, Marcin W., Porkka, Kimmo, Sekeres, Mikkael A., List, Alan, Mustjoki, Satu, Loughran, Thomas P., Maciejewski, Jaroslaw P.
Publicado em 2012

Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes

Por Sundaravel, Sriram, Duggan, Ryan, Bhagat, Tushar, Ebenezer, David L., Liu, Hui, Yu, Yiting, Bartenstein, Matthias, Unnikrishnan, Madhu, Karmakar, Subhradip, Liu, Ting-Chun, Torregroza, Ingrid, Quenon, Thomas, Anastasi, John, McGraw, Kathy L., Pellagatti, Andrea, Boultwood, Jacqueline, Yajnik, Vijay, Artz, Andrew, Le Beau, Michelle M., Steidl, Ulrich, List, Alan F., Evans, Todd, Verma, Amit, Wickrema, Amittha
Publicado no Proc Natl Acad Sci U S A (2015)

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Por Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Cleveland, John L., O’Neill, Luke A., Wei, Sheng, List, Alan F.
Publicado no Blood (2016)

Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis

Por Jerez, Andres, Sugimoto, Yuka, Makishima, Hideki, Verma, Amit, Jankowska, Anna M., Przychodzen, Bartlomiej, Visconte, Valeria, Tiu, Ramon V., O'Keefe, Christine L., Mohamedali, Azim M., Kulasekararaj, Austin G., Pellagatti, Andrea, McGraw, Kathy, Muramatsu, Hideki, Moliterno, Alison R., Sekeres, Mikkael A., McDevitt, Michael A., Kojima, Seiji, List, Alan, Boultwood, Jacqueline, Mufti, Ghulam J., Maciejewski, Jaroslaw P.
Publicado em 2012

STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients

Por Jerez, Andres, Clemente, Michael J., Makishima, Hideki, Rajala, Hanna, Gómez-Seguí, Ines, Olson, Thomas, McGraw, Kathy, Przychodzen, Bartlomiej, Kulasekararaj, Austin, Afable, Manuel, Husseinzadeh, Holleh D., Hosono, Naoko, LeBlanc, Francis, Lagström, Sonja, Zhang, Dan, Ellonen, Pekka, Tichelli, André, Nissen, Catherine, Lichtin, Alan E., Wodnar-Filipowicz, Aleksandra, Mufti, Ghulam J., List, Alan F., Mustjoki, Satu, Loughran, Thomas P., Maciejewski, Jaroslaw P.
Publicado em 2013