Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes

Anemia is the predominant clinical manifestation of myelodysplastic syndromes (MDS). Loss or deletion of chromosome 7 is commonly seen in MDS and leads to a poor prognosis. However, the identity of functionally relevant, dysplasia-causing, genes on 7q remains unclear. Dedicator of cytokinesis 4 (DOC...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Sundaravel, Sriram, Duggan, Ryan, Bhagat, Tushar, Ebenezer, David L., Liu, Hui, Yu, Yiting, Bartenstein, Matthias, Unnikrishnan, Madhu, Karmakar, Subhradip, Liu, Ting-Chun, Torregroza, Ingrid, Quenon, Thomas, Anastasi, John, McGraw, Kathy L., Pellagatti, Andrea, Boultwood, Jacqueline, Yajnik, Vijay, Artz, Andrew, Le Beau, Michelle M., Steidl, Ulrich, List, Alan F., Evans, Todd, Verma, Amit, Wickrema, Amittha
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655581/
https://ncbi.nlm.nih.gov/pubmed/26578796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516394112
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