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Loss of function of DOCK4 in myelodysplastic syndromes stem cells is restored by inhibitors of DOCK4 signaling networks
PURPOSE: MDS with deletion of chromosome 7q/7 (−7/(del)7q MDS) is associated with worse outcomes and needs novel insights into pathogenesis. Reduced expression of signaling protein DOCK4 in −7/(del)7q MDS patients leads to a block in hematopoietic stem cell (HSC) differentiation. Identification of t...
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| Publicat a: | Clin Cancer Res |
|---|---|
| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6744990/ https://ncbi.nlm.nih.gov/pubmed/31308061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0924 |
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