Loss of function of DOCK4 in myelodysplastic syndromes stem cells is restored by inhibitors of DOCK4 signaling networks

PURPOSE: MDS with deletion of chromosome 7q/7 (−7/(del)7q MDS) is associated with worse outcomes and needs novel insights into pathogenesis. Reduced expression of signaling protein DOCK4 in −7/(del)7q MDS patients leads to a block in hematopoietic stem cell (HSC) differentiation. Identification of t...

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Udgivet i:Clin Cancer Res
Main Authors: Sundaravel, Sriram, Kuo, Wen-Liang, Jeong, Jong J., Choudhary, Gaurav S., Gordon-Mitchell, Shanisha, Liu, Hui, Bhagat, Tushar D., McGraw, Kathy L., Gurbuxani, Sandeep K., List, Alan F., Verma, Amit, Wickrema, Amittha
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744990/
https://ncbi.nlm.nih.gov/pubmed/31308061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0924
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