Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41

In a subset of patients with non-del(5q) myelodysplastic syndrome (MDS), lenalidomide promotes erythroid lineage competence and effective erythropoiesis. To determine the mechanism by which lenalidomide promotes erythropoiesis, we investigated its action on erythropoietin receptor (EpoR) cellular dy...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Basiorka, Ashley A, McGraw, Kathy L, De Ceuninck, Leentje, Griner, Lori N, Zhang, Ling, Clark, Justine A, Caceres, Gisela, Sokol, Lubomir, Komrokji, Rami S, Reuther, Gary W, Wei, Sheng, Tavernier, Jan, List, Alan F
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911265/
https://ncbi.nlm.nih.gov/pubmed/27197154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1756
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