The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is activation of the NLRP3 inflammasome, which drives clonal expansion and pyroptotic cell death. Independent of genotype, MDS hema...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Cleveland, John L., O’Neill, Luke A., Wei, Sheng, List, Alan F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2016
Konular:
Myeloid Neoplasia
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179338/
https://ncbi.nlm.nih.gov/pubmed/27737891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-07-730556
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