The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is activation of the NLRP3 inflammasome, which drives clonal expansion and pyroptotic cell death. Independent of genotype, MDS hema...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Cleveland, John L., O’Neill, Luke A., Wei, Sheng, List, Alan F.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2016
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5179338/
https://ncbi.nlm.nih.gov/pubmed/27737891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-07-730556
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