TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients

Stabilization of p53 in erythroid precursors in response to nucleosomal stress underlies the hypoplastic anemia in myelodysplastic syndromes (MDS) with chromosome 5q deletion [del(5q)]. We investigated whether cenersen, a clinically active 20-mer antisense oligonucleotide complementary to TP53 exon1...

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主要な著者: Caceres, Gisela, McGraw, Kathy, Yip, Bon Ham, Pellagatti, Andrea, Johnson, Joseph, Zhang, Ling, Liu, Kenian, Zhang, Lan Min, Fulp, William J., Lee, Ji-Hyun, Al Ali, Najla H., Basiorka, Ashley, Smith, Larry J., Daugherty, F. Joseph, Littleton, Neil, Wells, Richard A., Sokol, Lubomir, Wei, Sheng, Komrokji, Rami S., Boultwood, Jacqueline, List, Alan F.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2013
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791697/
https://ncbi.nlm.nih.gov/pubmed/24043769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311055110
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