Lenalidomide Promotes p53 Degradation by Inhibiting MDM2 Auto-ubiquitination in Myelodysplastic Syndrome with Chromosome 5q Deletion

Allelic deletion of the RPS14 gene is a key effector of the hypoplastic anemia in patients with myelodysplastic syndrome (MDS) and chromosome 5q deletion [del(5q)]. Disruption of ribosome integrity liberates free ribosomal proteins to bind to and trigger degradation of MDM2, with consequent p53 tran...

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Detalhes bibliográficos
Main Authors: Wei, Sheng, Chen, Xianghong, McGraw, Kathy, Zhang, Ling, Komrokji, Rami, Clark, Justine, Caceres, Gisela, Billingsley, Debbie, Sokol, Lubomir, Lancet, Jeffrey, Fortenbery, Nicole, Zhou, Junmin, Eksioglu, Erika A., Sallman, David, Wang, Huaquan, Epling-Burnette, Pearlie K., Djeu, Julie, Maciejewski, Jaroslaw P., Sekeres, Mikkael, List, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3751397/
https://ncbi.nlm.nih.gov/pubmed/22525275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.139
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