Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms

ανά Chouchani, Edward T., Kazak, Lawrence, Spiegelman, Bruce M.
Τόπος έκδοσης J Biol Chem (2017)

Multiplexed isobaric tag-based profiling of seven murine tissues following in vivo nicotine treatment using a minimalistic proteomics strategy

ανά Paulo, Joao A., Jedrychowski, Mark P., Chouchani, Edward T., Kazak, Lawrence, Gygi, Steven P.
Τόπος έκδοσης Proteomics (2018)

Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts

ανά Reyes, Aurelio, Kazak, Lawrence, Wood, Stuart R., Yasukawa, Takehiro, Jacobs, Howard T., Holt, Ian J.
Έκδοση 2013

mTOR as a central regulator of lifespan and aging

ανά Papadopoli, David, Boulay, Karine, Kazak, Lawrence, Pollak, Michael, Mallette, Frédérick A., Topisirovic, Ivan, Hulea, Laura
Τόπος έκδοσης F1000Res (2019)

A Cryptic Targeting Signal Creates a Mitochondrial FEN1 Isoform with Tailed R-Loop Binding Properties

ανά Kazak, Lawrence, Reyes, Aurelio, He, Jiuya, Wood, Stuart R., Brea-Calvo, Gloria, Holen, Torgeir T., Holt, Ian J.
Έκδοση 2013

Tumor-derived PTHrP Triggers Adipose Tissue Browning and Cancer Cachexia

ανά Kir, Serkan, White, James P., Kleiner, Sandra, Kazak, Lawrence, Cohen, Paul, Baracos, Vickie E., Spiegelman, Bruce M.
Τόπος έκδοσης Nature (2014)

Fat cells directly sense temperature to activate thermogenesis

ανά Ye, Li, Wu, Jun, Cohen, Paul, Kazak, Lawrence, Khandekar, Melin J., Jedrychowski, Mark P., Zeng, Xing, Gygi, Steven P., Spiegelman, Bruce M.
Έκδοση 2013

Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication

ανά Cluett, Tricia J, Akman, Gokhan, Reyes, Aurelio, Kazak, Lawrence, Mitchell, Alice, Wood, Stuart R, Spinazzola, Antonella, Spelbrink, Johannes N, Holt, Ian J
Τόπος έκδοσης Nucleic Acids Res (2018)

Mitochondrial Patch-Clamp of Beige Adipocytes Reveals UCP1-positive and UCP1-negative Cells Both Exhibiting Futile Creatine Cycling

ανά Bertholet, Ambre M., Kazak, Lawrence, Chouchani, Edward T., Bogaczyńska, Marta G., Paranjpe, Ishan, Wainwright, Gabrielle L., Bétourné, Alexandre, Kajimura, Shingo, Spiegelman, Bruce M., Kirichok, Yuriy
Τόπος έκδοσης Cell Metab (2017)

Alternative translation initiation augments the human mitochondrial proteome

ανά Kazak, Lawrence, Reyes, Aurelio, Duncan, Anna L., Rorbach, Joanna, Wood, Stuart R., Brea-Calvo, Gloria, Gammage, Payam A., Robinson, Alan J., Minczuk, Michal, Holt, Ian J.
Έκδοση 2013

IRF3 promotes adipose inflammation and insulin resistance and represses browning

ανά Kumari, Manju, Wang, Xun, Lantier, Louise, Lyubetskaya, Anna, Eguchi, Jun, Kang, Sona, Tenen, Danielle, Roh, Hyun Cheol, Kong, Xingxing, Kazak, Lawrence, Ahmad, Rasheed, Rosen, Evan D.
Τόπος έκδοσης J Clin Invest (2016)

Brown adipose tissue controls skeletal muscle function via the secretion of myostatin

ανά Kong, Xingxing, Yao, Ting, Zhou, Peng, Kazak, Lawrence, Tenen, Danielle, Lyubetskaya, Anna, Dawes, Brian A., Tsai, Linus, Kahn, Barbara B., Spiegelman, Bruce M., Liu, Tiemin, Rosen, Evan D.
Τόπος έκδοσης Cell Metab (2018)

H(+) Transport is an Integral Function of the Mitochondrial ADP/ATP Carrier

ανά Bertholet, Ambre M., Chouchani, Edward T., Kazak, Lawrence, Angelin, Alessia, Fedorenko, Andriy, Long, Jonathan Z., Vidoni, Sara, Garrity, Ryan, Cho, Joonseok, Terada, Naohiro, Wallace, Douglas C., Spiegelman, Bruce M., Kirichok, Yuriy
Τόπος έκδοσης Nature (2019)

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

ανά Kazak, Lawrence, Chouchani, Edward T., Jedrychowski, Mark P., Erickson, Brian K., Shinoda, Kosaku, Cohen, Paul, Vetrivelan, Ramalingam, Lu, Gina Z., Laznik-Bogoslavski, Dina, Hasenfuss, Sebastian C., Kajimura, Shingo, Gygi, Steve P., Spiegelman, Bruce M.
Τόπος έκδοσης Cell (2015)

Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy

ανά Khandekar, Melin J., Banks, Alexander S., Laznik-Bogoslavski, Dina, White, James P., Choi, Jang Hyun, Kazak, Lawrence, Lo, James C., Cohen, Paul, Wong, Kwok-Kin, Kamenecka, Theodore M., Griffin, Patrick R., Spiegelman, Bruce M.
Τόπος έκδοσης Proc Natl Acad Sci U S A (2018)

Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity

ανά Kazak, Lawrence, Chouchani, Edward T., Lu, Gina Z., Jedrychowski, Mark P., Bare, Curtis J., Mina, Amir, Kumari, Manju, Zhang, Song, Vuckovic, Ivan, Laznik-Bogoslavski, Dina, Dzeja, Petras, Banks, Alexander S., Rosen, Evan D., Spiegelman, Bruce M.
Τόπος έκδοσης Cell Metab (2017)

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

ανά Chouchani, Edward T., Kazak, Lawrence, Jedrychowski, Mark P., Lu, Gina Z., Erickson, Brian K., Szpyt, John, Pierce, Kerry A., Laznik-Bogoslavski, Dina, Vetrivelan, Ramalingam, Clish, Clary B., Robinson, Alan J., Gygi, Steve P., Spiegelman, Bruce M.
Τόπος έκδοσης Nature (2016)

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity

ανά Kazak, Lawrence, Chouchani, Edward T., Lu, Gina Z., Jedrychowski, Mark P., Bare, Curtis J., Mina, Amir I., Kumari, Manju, Zhang, Song, Vuckovic, Ivan, Laznik-Bogoslavski, Dina, Dzeja, Petras, Banks, Alexander S., Rosen, Evan D., Spiegelman, Bruce M.
Τόπος έκδοσης Cell Metab (2017)

Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity

ανά Jedrychowski, Mark P., Lu, Gina Z., Szpyt, John, Mariotti, Marco, Garrity, Ryan, Paulo, Joao A., Schweppe, Devin K., Laznik-Bogoslavski, Dina, Kazak, Lawrence, Murphy, Michael P., Gladyshev, Vadim N., Gygi, Steven P., Chouchani, Edward T., Spiegelman, Bruce M.
Τόπος έκδοσης Proc Natl Acad Sci U S A (2020)

IRF4 is a key thermogenic transcriptional partner of PGC-1α

ανά Kong, Xingxing, Banks, Alexander, Liu, Tiemin, Kazak, Lawrence, Rao, Rajesh R., Cohen, Paul, Wang, Xun, Yu, Songtao, Lo, James C., Tseng, Yu-Hua, Cypess, Aaron M., Xue, Ruidan, Kleiner, Sandra, Kang, Sona, Spiegelman, Bruce M., Rosen, Evan D.
Έκδοση 2014