Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy

The peroxisome-proliferator receptor-γ (PPARγ) is expressed in multiple cancer types. Recently, our group has shown that PPARγ is phosphorylated on serine 273 (S273), which selectively modulates the transcriptional program controlled by this protein. PPARγ ligands, including thiazolidinediones (TZDs...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Khandekar, Melin J., Banks, Alexander S., Laznik-Bogoslavski, Dina, White, James P., Choi, Jang Hyun, Kazak, Lawrence, Lo, James C., Cohen, Paul, Wong, Kwok-Kin, Kamenecka, Theodore M., Griffin, Patrick R., Spiegelman, Bruce M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776997/
https://ncbi.nlm.nih.gov/pubmed/29295932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717776115
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