Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy

The peroxisome-proliferator receptor-γ (PPARγ) is expressed in multiple cancer types. Recently, our group has shown that PPARγ is phosphorylated on serine 273 (S273), which selectively modulates the transcriptional program controlled by this protein. PPARγ ligands, including thiazolidinediones (TZDs...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Khandekar, Melin J., Banks, Alexander S., Laznik-Bogoslavski, Dina, White, James P., Choi, Jang Hyun, Kazak, Lawrence, Lo, James C., Cohen, Paul, Wong, Kwok-Kin, Kamenecka, Theodore M., Griffin, Patrick R., Spiegelman, Bruce M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776997/
https://ncbi.nlm.nih.gov/pubmed/29295932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717776115
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