Obesity-linked phosphorylation of PPARγ by cdk5 is a direct target of the anti-diabetic PPARγ ligands

Obesity induced in mice by high-fat feeding activates the protein kinase cdk5 in adipose tissues. This results in phosphorylation of the nuclear receptor PPARγ, a dominant regulator of adipogenesis and fat cell gene expression, at serine 273. This modification of PPARγ does not alter its adipogenic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Choi, Jang Hyun, Banks, Alexander S., Estall, Jennifer L., Kajimura, Shingo, Bostrom, Pontus, Laznik, Dina, Ruas, Jorge L., Chalmers, Michael J., Kamenecka, Theodore M., Bluher, Matthias, Griffin, Patrick R., Spiegelman, Bruce M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987584/
https://ncbi.nlm.nih.gov/pubmed/20651683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09291
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados