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Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism

Ligand binding to proteins is not a static process, but rather involves a number of complex dynamic transitions. A flexible ligand can change conformation upon binding its target. The conformation and dynamics of a protein can change to facilitate ligand binding. The conformation of the ligand, howe...

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Bibliografski detalji
Glavni autori: Hughes, Travis S., Chalmers, Michael J., Novick, Scott, Kuruvilla, Dana S., Chang, Mi Ra, Kamenecka, Theodore M., Rance, Mark, Johnson, Bruce A., Burris, Thomas P., Griffin, Patrick R., Kojetin, Douglas J.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278220/
https://ncbi.nlm.nih.gov/pubmed/22244763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.10.018
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