Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism

Ligand binding to proteins is not a static process, but rather involves a number of complex dynamic transitions. A flexible ligand can change conformation upon binding its target. The conformation and dynamics of a protein can change to facilitate ligand binding. The conformation of the ligand, howe...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hughes, Travis S., Chalmers, Michael J., Novick, Scott, Kuruvilla, Dana S., Chang, Mi Ra, Kamenecka, Theodore M., Rance, Mark, Johnson, Bruce A., Burris, Thomas P., Griffin, Patrick R., Kojetin, Douglas J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278220/
https://ncbi.nlm.nih.gov/pubmed/22244763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.10.018
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