Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication

Mammalian mitochondria operate multiple mechanisms of DNA replication. In many cells and tissues a strand-asynchronous mechanism predominates over coupled leading and lagging-strand DNA synthesis. However, little is known of the factors that control or influence the different mechanisms of replicati...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Cluett, Tricia J, Akman, Gokhan, Reyes, Aurelio, Kazak, Lawrence, Mitchell, Alice, Wood, Stuart R, Spinazzola, Antonella, Spelbrink, Johannes N, Holt, Ian J
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237803/
https://ncbi.nlm.nih.gov/pubmed/30239839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky852
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