Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA

Expression of a proof-reading deficient form of mitochondrial DNA (mtDNA) polymerase γ, POLG, causes early death accompanied by features of premature ageing in mouse. However, the mechanism of cellular senescence remains unresolved. In addition to high levels of point mutations of mtDNA, the POLG mu...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bailey, Laura J., Cluett, Tricia J., Reyes, Aurelio, Prolla, Tom A., Poulton, Joanna, Leeuwenburgh, Christiaan, Holt, Ian J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2009
Gaiak:
Genome Integrity, Repair and Replication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673436/
https://ncbi.nlm.nih.gov/pubmed/19244310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp091
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