The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome

FRAXA is one of a number of fragile sites in human chromosomes that are induced by agents like fluorodeoxyuridine (FdU) that affect intracellular thymidylate levels. FRAXA coincides with a >200 CGG•CCG repeat tract in the 5′ UTR of the FMR1 gene, and alleles prone to fragility are associated with...

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Détails bibliographiques
Auteurs principaux: Kumari, Daman, Somma, Valentina, Nakamura, Asako J., Bonner, William M., D’Ambrosio, Ettoré, Usdin, Karen
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2009
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715245/
https://ncbi.nlm.nih.gov/pubmed/19465392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp391
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