Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase

Multiple DNA double-strand break (DSB) repair pathways are active in S phase of the cell cycle; however, DSBs are primarily repaired by homologous recombination (HR) in this cell cycle phase. As the non-homologous end-joining (NHEJ) factor, Ku70/80 (Ku), is quickly recruited to DSBs in S phase, we h...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Lee, Kyung-Jong, Saha, Janapriya, Sun, Jingxin, Fattah, Kazi R., Wang, Shu-Chi, Jakob, Burkhard, Chi, Linfeng, Wang, Shih-Ya, Taucher-Scholz, Gisela, Davis, Anthony J., Chen, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770226/
https://ncbi.nlm.nih.gov/pubmed/26712563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1499
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