DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

DNA double-strand breaks (DSBs) can induce chromosomal aberrations and carcinogenesis and their correct repair is crucial for genetic stability. The cellular response to DSBs depends on damage signaling including the phosphorylation of the histone H2AX (γH2AX). However, a lack of γH2AX formation in...

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Main Authors: Jakob, Burkhard, Splinter, Jörn, Conrad, Sandro, Voss, Kay-Obbe, Zink, Daniele, Durante, Marco, Löbrich, Markus, Taucher-Scholz, Gisela
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159438/
https://ncbi.nlm.nih.gov/pubmed/21511815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr230
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