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DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

DNA double-strand breaks (DSBs) can induce chromosomal aberrations and carcinogenesis and their correct repair is crucial for genetic stability. The cellular response to DSBs depends on damage signaling including the phosphorylation of the histone H2AX (γH2AX). However, a lack of γH2AX formation in...

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Bibliografische gegevens
Hoofdauteurs: Jakob, Burkhard, Splinter, Jörn, Conrad, Sandro, Voss, Kay-Obbe, Zink, Daniele, Durante, Marco, Löbrich, Markus, Taucher-Scholz, Gisela
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159438/
https://ncbi.nlm.nih.gov/pubmed/21511815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr230
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