Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK

DNA double-strand breaks (DSB) are considered as the most deleterious DNA lesions, and their repair is further complicated by increasing damage complexity. However, the molecular effects of clustered lesions are yet not fully understood. As the locally restricted phosphorylation of H2AX to form γH2A...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Meyer, Barbara, Voss, Kay-Obbe, Tobias, Frank, Jakob, Burkhard, Durante, Marco, Taucher-Scholz, Gisela
التنسيق: Artigo
اللغة:Inglês
منشور في: Oxford University Press 2013
الموضوعات:
Genome Integrity, Repair and Replication
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695524/
https://ncbi.nlm.nih.gov/pubmed/23620287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt304
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