Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK

DNA double-strand breaks (DSB) are considered as the most deleterious DNA lesions, and their repair is further complicated by increasing damage complexity. However, the molecular effects of clustered lesions are yet not fully understood. As the locally restricted phosphorylation of H2AX to form γH2A...

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Bibliografiske detaljer
Main Authors: Meyer, Barbara, Voss, Kay-Obbe, Tobias, Frank, Jakob, Burkhard, Durante, Marco, Taucher-Scholz, Gisela
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695524/
https://ncbi.nlm.nih.gov/pubmed/23620287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt304
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