Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

DNA damage encountered by DNA replication forks poses risks of genome destabilization, a precursor to carcinogenesis. Damage checkpoint systems cause cell cycle arrest, promote repair and induce programed cell death when damage is severe. Checkpoints are critical parts of the DNA damage response net...

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Hoofdauteurs: Liu, Shengqin, Opiyo, Stephen O., Manthey, Karoline, Glanzer, Jason G., Ashley, Amanda K., Amerin, Courtney, Troksa, Kyle, Shrivastav, Meena, Nickoloff, Jac A., Oakley, Greg G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2012
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510507/
https://ncbi.nlm.nih.gov/pubmed/22977173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks849
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