Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

DNA damage encountered by DNA replication forks poses risks of genome destabilization, a precursor to carcinogenesis. Damage checkpoint systems cause cell cycle arrest, promote repair and induce programed cell death when damage is severe. Checkpoints are critical parts of the DNA damage response net...

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Detalhes bibliográficos
Main Authors: Liu, Shengqin, Opiyo, Stephen O., Manthey, Karoline, Glanzer, Jason G., Ashley, Amanda K., Amerin, Courtney, Troksa, Kyle, Shrivastav, Meena, Nickoloff, Jac A., Oakley, Greg G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510507/
https://ncbi.nlm.nih.gov/pubmed/22977173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks849
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