A kinetochore-based ATM/ATR-independent DNA damage checkpoint maintains genomic integrity in trypanosomes

DNA damage-induced cell cycle checkpoints serve as surveillance mechanisms to maintain genomic stability, and are regulated by ATM/ATR-mediated signaling pathways that are conserved from yeast to humans. Trypanosoma brucei, an early divergent microbial eukaryote, lacks key components of the conventi...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Zhou, Qing, Pham, Kieu T M, Hu, Huiqing, Kurasawa, Yasuhiro, Li, Ziyin
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736141/
https://ncbi.nlm.nih.gov/pubmed/31147720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz476
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