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DNA Damage Activates the SAC in an ATM/ATR-Dependent Manner, Independently of the Kinetochore

The DNA damage checkpoint and the spindle assembly checkpoint (SAC) are two important regulatory mechanisms that respond to different lesions. The DNA damage checkpoint detects DNA damage, initiates protein kinase cascades, and inhibits the cell cycle. The SAC relies on kinetochore-dependent assembl...

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Detalhes bibliográficos
Main Authors: Kim, Eun Mi, Burke, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265443/
https://ncbi.nlm.nih.gov/pubmed/18454191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000015
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