Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis

The POT1 (protection of telomeres) protein binds the single-stranded G-rich overhang and is essential for both telomere end protection and telomere length regulation. Telomeric binding of POT1 is enhanced by its interaction with TPP1. In this study, we demonstrate that mouse Tpp1 confers telomere en...

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Detaylı Bibliyografya
Asıl Yazarlar: Guo, Xiaolan, Deng, Yibin, Lin, Yahong, Cosme-Blanco, Wilfredo, Chan, Suzanne, He, Hua, Yuan, Guohua, Brown, Eric J, Chang, Sandy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2080807/
https://ncbi.nlm.nih.gov/pubmed/17948054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601893
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