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Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis
The POT1 (protection of telomeres) protein binds the single-stranded G-rich overhang and is essential for both telomere end protection and telomere length regulation. Telomeric binding of POT1 is enhanced by its interaction with TPP1. In this study, we demonstrate that mouse Tpp1 confers telomere en...
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| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2007
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2080807/ https://ncbi.nlm.nih.gov/pubmed/17948054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601893 |
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