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Telomere dysfunction and Tumor Suppression-the Senescence Connection
Long lived organisms such as humans have evolved several intrinsic tumor suppressor mechanisms to combat the slew of oncogenic somatic mutations that constantly arise in proliferating stem cell compartments. One of these anti-cancer barriers is the telomere, a specialized nucleoprotein that caps the...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3688269/ https://ncbi.nlm.nih.gov/pubmed/18500246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc2393 |
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