Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

Werner Syndrome (WS) is characterized by premature aging, genomic instability, and cancer. The combined impact of WRN helicase deficiency and limiting telomere reserves is central to disease pathogenesis. Here, we report that cells doubly deficient for telomerase and WRN helicase show chromosomal ab...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Laud, Purnima R., Multani, Asha S., Bailey, Susan M., Wu, Ling, Ma, Jin, Kingsley, Charles, Lebel, Michel, Pathak, Sen, DePinho, Ronald A., Chang, Sandy
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2005
Teme:
Research Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276730/
https://ncbi.nlm.nih.gov/pubmed/16264192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1321305
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items