Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

Werner Syndrome (WS) is characterized by premature aging, genomic instability, and cancer. The combined impact of WRN helicase deficiency and limiting telomere reserves is central to disease pathogenesis. Here, we report that cells doubly deficient for telomerase and WRN helicase show chromosomal ab...

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Detalhes bibliográficos
Main Authors: Laud, Purnima R., Multani, Asha S., Bailey, Susan M., Wu, Ling, Ma, Jin, Kingsley, Charles, Lebel, Michel, Pathak, Sen, DePinho, Ronald A., Chang, Sandy
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276730/
https://ncbi.nlm.nih.gov/pubmed/16264192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1321305
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