Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

Werner Syndrome (WS) is characterized by premature aging, genomic instability, and cancer. The combined impact of WRN helicase deficiency and limiting telomere reserves is central to disease pathogenesis. Here, we report that cells doubly deficient for telomerase and WRN helicase show chromosomal ab...

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Autores principales: Laud, Purnima R., Multani, Asha S., Bailey, Susan M., Wu, Ling, Ma, Jin, Kingsley, Charles, Lebel, Michel, Pathak, Sen, DePinho, Ronald A., Chang, Sandy
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2005
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276730/
https://ncbi.nlm.nih.gov/pubmed/16264192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1321305
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