Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

Werner Syndrome (WS) is characterized by premature aging, genomic instability, and cancer. The combined impact of WRN helicase deficiency and limiting telomere reserves is central to disease pathogenesis. Here, we report that cells doubly deficient for telomerase and WRN helicase show chromosomal ab...

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Autors principals: Laud, Purnima R., Multani, Asha S., Bailey, Susan M., Wu, Ling, Ma, Jin, Kingsley, Charles, Lebel, Michel, Pathak, Sen, DePinho, Ronald A., Chang, Sandy
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2005
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276730/
https://ncbi.nlm.nih.gov/pubmed/16264192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1321305
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