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Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression

Telomerase activation is a common feature of most advanced human cancers and is postulated to restore genomic stability to a level permissive for cell viability and tumor progression. Here, we used genetically defined transformed mouse embryonic fibroblast (MEF) cultures derived from late generation...

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Detalhes bibliográficos
Main Authors: Chang, Sandy, Khoo, Christine M., Naylor, Maria L., Maser, Richard S., DePinho, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC195968/
https://ncbi.nlm.nih.gov/pubmed/12514102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1029903
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