DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes

Mouse oocytes carrying DNA damage arrest in meiosis I, thereby preventing creation of embryos with deleterious mutations. The arrest is dependent on activation of the spindle assembly checkpoint, which results in anaphase-promoting complex (APC) inhibition. However, little is understood about how th...

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Pubblicato in:Development
Autori principali: Lane, Simon I. R., Morgan, Stephanie L., Wu, Tianyu, Collins, Josie K., Merriman, Julie A., ElInati, Elias, Turner, James M., Jones, Keith T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665484/
https://ncbi.nlm.nih.gov/pubmed/28851706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.153965
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