DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes

Mouse oocytes carrying DNA damage arrest in meiosis I, thereby preventing creation of embryos with deleterious mutations. The arrest is dependent on activation of the spindle assembly checkpoint, which results in anaphase-promoting complex (APC) inhibition. However, little is understood about how th...

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Bibliografiska uppgifter
I publikationen:Development
Huvudupphovsmän: Lane, Simon I. R., Morgan, Stephanie L., Wu, Tianyu, Collins, Josie K., Merriman, Julie A., ElInati, Elias, Turner, James M., Jones, Keith T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Company of Biologists Ltd 2017
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665484/
https://ncbi.nlm.nih.gov/pubmed/28851706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.153965
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