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DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes

Mouse oocytes carrying DNA damage arrest in meiosis I, thereby preventing creation of embryos with deleterious mutations. The arrest is dependent on activation of the spindle assembly checkpoint, which results in anaphase-promoting complex (APC) inhibition. However, little is understood about how th...

詳細記述

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書誌詳細
出版年:Development
主要な著者: Lane, Simon I. R., Morgan, Stephanie L., Wu, Tianyu, Collins, Josie K., Merriman, Julie A., ElInati, Elias, Turner, James M., Jones, Keith T.
フォーマット: Artigo
言語:Inglês
出版事項: The Company of Biologists Ltd 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665484/
https://ncbi.nlm.nih.gov/pubmed/28851706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.153965
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