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DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint

Extensive damage to maternal DNA during meiosis causes infertility, birth defects and abortions. However, it is unknown if fully grown oocytes have a mechanism to prevent the creation of DNA-damaged embryos. Here we show that DNA damage activates a pathway involving the spindle assembly checkpoint (...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Collins, Josie K., Lane, Simon I. R., Merriman, Julie A., Jones, Keith T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Pub. Group 2015
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659839/
https://ncbi.nlm.nih.gov/pubmed/26522232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9553
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