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DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint

Extensive damage to maternal DNA during meiosis causes infertility, birth defects and abortions. However, it is unknown if fully grown oocytes have a mechanism to prevent the creation of DNA-damaged embryos. Here we show that DNA damage activates a pathway involving the spindle assembly checkpoint (...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Collins, Josie K., Lane, Simon I. R., Merriman, Julie A., Jones, Keith T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659839/
https://ncbi.nlm.nih.gov/pubmed/26522232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9553
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